Wednesday, September 7, 2011

Efficacy of amprolium in goat kids

Although amprolium (Corid) is approved in many countries for the treatment of Eimeria (coccidia) infections in animals, there is little data available on the efficacy and proper dose for use in goat kids.

Researchers at North Carolina State University conducted a clinical trial to determine the efficacy of two different doses of amprolium in goat kids heavily infected with pathogenic Eimeria species.

Forty Boer kids (3-4 mos. of age) were treated orally with 9.6% amprolium for five days at a dose of either 10 mg/kg or 50 mg/kg.  Fecal samples were collected at day 0 and 7 and a pooled sample was analyzed to identify the species of Eimeria.

At day 7, the Eimeria oocyte per gram concentrations were significantly reduced in the kids that received amprolium at a dose of 50 mg/kg; however concentrations were not significantly different in the kids that received amprolium at a dose of 10 mg/kg.

Kids that received the higher dose of amprolium had normal fecal consistencies by day 7, but diarrhea was still present in the kids that received the lower dose of amprolium.

Of the 100 oocytes identified in the pooled sample, 52% were identified as E. christenseni, a pathogenic strain of Eimeria.

The researchers concluded that amprolium can be an effective treatment for Eimeria infection in goat kids, but that higher doses (50 mg/kg) should be given.

Coccidiosis can be a major disease problem in goats (and sheep). Amprolium (Corid) is not FDA-approved for use in goats (or sheep), but can be prescribed by a veterinarian under the extra-label drug rules.

Read full article at Kenes Group

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